Clinical Trials & Research
Working Towards a Future Free from HypoPARA
The HypoPARAthyroidism Association has always advocated for participation in patient studies and other investigative medical initiatives. Medical research and patient participation is necessary if medical science is to be advanced, and patient’s quality of life improved.
Types of Clinical Trials
Some trials are drug trials which mean you will receive medication as part of the trial. Some are natural history or other forms of investigational studies that do not involve any medication. There are also trials like the one below that is for allotransplantation (a surgical procedure) or ones that are diagnostic in nature. Always make sure to understand what type of trial you are signing up for as well as discuss the trial with your individual doctor.
If you have questions regarding what it is like to participate in a clinical trial please reach out to the association with your specific question(s). Several of our board members have participated in trials.
Current Clinical Trials
There are several clinical trials taking place on hypoPARAthyroidism at this time. You can always check for updates online at ClinicalTrials.gov or CenterWatch.com for the complete list of current and upcoming research protocols.
A Phase 2 Trial Investigating the Safety, Tolerability and Efficacy of EXT608 in Adults With Hypoparathyroidism
Brief Summary
The goal of this clinical trial is to investigate the safety, tolerability and efficacy of EXT608 in adults with hypoparathyroidism.
Official Title
A Phase 2, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Multiple Ascending Dose Trial Investigating the Safety, Tolerability and Efficacy of EXT608 in Adults With Hypoparathyroidism
Evaluating the Safety and Efficacy of AMOR-1 as a Treatment for Hypocalcemia Associated With Hypoparathyroidism in Adults
Brief Summary
This clinical trial aims to evaluate the efficacy and safety of AMOR-1, consisting of Amorphous Calcium Carbonate (ACC) as the active drug substance, in treating hypocalcemia in adults with hypoparathyroidism.
AMOR-1 Trial
Parathyroid Allotransplantation in Medically Refractory HypoPARAthyroidism (PATH)
This study is to have parathyroid tissue transplanted.
LEARN MORE About Path
CLARIFY: ADH1 and ADH2 Disease Monitoring Study (DMS)
Sponsored by Calcilytix Therapeutics, Inc. (a BridgeBio company), this disease monitoring study (DMS) includes adult and pediatric participants with ADH1 or ADH2. The study is designed to gain a better understanding of the standard of care practices and treatments in a real-world setting.
Natural History Study – SHINE
A natural history study is a preplanned observational study intended to track the course of the disease. Its purpose is to identify demographic, genetic, environmental, and other variables (e.g., treatment modalities, concomitant medications) that correlate with the disease’s development and outcomes. Natural history studies are likely to include patients receiving the current standard of care and/or emergent care, which may alter some manifestations of the disease.
LEARN MORE about Shine
Additional Drug Trials & Research Studies
Finding Clinical Trials
You can always check for updates at ClinicalTrials.gov website or CenterWatch for the complete list of current and upcoming research protocols.
ClinicalTrails.gov
ClinicalTrials.gov is a database of privately and publicly funded clinical studies conducted around the world. It is a resource provided by the U.S. National Library of Medicine.
CenterWatch
CenterWatch first launched the Clinical Trials Listing Service in 1994 to assist patients in finding and volunteering for clinical trials. Today, CenterWatch has the largest online listing of actively recruiting clinical trials and is one of the most trusted resources for patients interested in clinical trial participation receiving more than 1.5 million unique patients visitors annually.